As the Baby-Boom generation ages, the number of people with brain disease will increase substantially. This will include progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as well as Parkinson’s disease, Alzheimer’s disease, and other related disorders. Both PSP and CBD are devastating neurodegenerative diseases that ultimately prove fatal. Although it is very rare for either disease to be found in more than one member of any family, an abnormal gene has been found that contributes to the cause of both. To develop methods for prevention and therapy, it is essential to understand the full genetic component of these diseases. This is now possible.

The CurePSP Genetics Program is a multi-year venture sponsored and supported by CurePSP (The Society for Progressive Supranuclear Palsy). Our goal is to search the entire genome for genes related to PSP and CBD and to identify previously unsuspected abnormal biochemical pathways against which scientists may be able to target therapeutic interventions.

All activities will be carried out by the CurePSP Genetics Consortium, composed of neurologists, geneticists, and other scientists from the United States, the United Kingdom, and Germany working in collaboration with neuroscientists throughout the world.

To read more about the program, click here or to see the researchers and leadership associated with this program, click here.